2021-07-20 16:40:20 广州仁医医疗 535



作者:Prof. Mayer


    摘 要    

The new development and finally the general acceptance of surgical techniques among the worldwide surgical community sometimes create fascinating stories. This is also true for the history of endoscopic lumbar spine surgery. In the last 100 years there was a “natural” evolution of surgical techniques with continuous improvement and “refinement” of lumbar decompression techniques towards less invasive operations with the final “endpoint” of microsurgery. However the application of percutaneous, image-guided, and endoscopic technologies has revolutionized minimally invasive surgery. This article describes the history of endoscopic lumbar spine surgery and its major milestones and protagonists which have helped to make endoscopic lumbar spine surgery “disruptive” minimally invasive surgical technology which has changed the world of lumbar decompression surgery.

“The past is the mother of the future”

Henri Cartier Bresson, French Photographer,1908-2004




   简 介   

Development and progress in spinal surgery have always been characterized by “back-and-forth movements” in clinical applications of technical innovations. Most evolutionary technical improvements which seemed to have a logical indication spectrum, with adequate feasibility and a perspective to improve early or late outcomes, have sooner or later become “standard” with a worldwide market penetration. A good example of such a development is anterior cervical discectomy and fusion (ACDF). It all started with the Cloward and Smith-Robinson technique , which was improved with the development of plates to support and fix the bone grafts. The bone grafts were replaced by cages made from different materials, and further technical improvement has led to the use of cages as stand-alone devices recently. This is a typical simple example of a continuous evolution of a surgical technique.

The lesson we can learn from this is that if a technical improvement follows the needs of the surgeon and if it improves or standardizes a surgical technique and its outcomes, the acceptance among the surgical community will be logical and high.



History of Lumbar Disc Surgery


Part 1: From Complete Laminectomy to Microsurgical/Microendoscopic Techniques


The history of lumbar discectomy and lumbar decompression is one of the most fascinating chapters of spine surgery which has taught us a number of important lessons.

It was in 1909 when Krause and Oppenheim described the first lumbar discectomy (Figure 1). Erroneously they described the herniated disc as a chondroma of the lumbar spinal canal. Only 2 years later Goldthwaite and Middleton were the first to describe a herniated nucleus pulposus as a reason of low back pain and sciatica (Figure 2)




Figure 1: F Krause and H Oppenheim: first surgical removal of a “chondroma” of the spinal canal 1909.

图1:F Krause和H Oppenheim:1909年首次手术切除椎管内的“软骨瘤”。


Figure 2: JE Goldthwaite: first description of herniated nucleus pulposus as reason for sciatica, 1911.

图2 :JE Goldthwaite:1911年首次描述髓核突出是坐骨神经痛的原因。

And it took another 11 years until Adson came up with the first report about surgical removal of herniated nucleus pulposus (Figure 3).



Figure 3: AW Adson: first description of surgical removal of herniated nucleus pulposus, 1922.

图3 AW Adson:1922年首次报道手术切除突出髓核。

However, like very often in medical history the merits for the first disc surgeries went to two other colleagues, namely, Mixter and Barr, who still are considered as having been the “first disc surgeons” in 1934 (Figure 4). They actually published the first series of successful disc operations in 1934. Their technique however was a complete laminectomy and some of the disc herniations were removed through a transdural approach.



Figure 4: WJ Mixter: first case series of surgical removal of herniated discs 1934.

图4:WJ Mixter:1934年第一批椎间盘切除手术系列

It was obvious from the beginning that this was a very traumatic approach with the potential of a variety of complications including dural leaks and segmental instability as well as disabling back pain.

The search for less damaging approaches had started. Only 5 years later, Love described the first interlaminar approach which became the standard procedure for many years (Figure 5). But even though the rate of major surgical complications dropped over time, the problem of postoperative back pain and rapid progression of disc degeneration due to aggressive disc removal affected the clinical outcomes.




Figure 5: JG Love: first description of interlaminar approach, 1939.

图5:JG Love:1939年首次报道了经椎板间入路

While surgery led to a significant improvement of nerve root compression signs, patient satisfaction was impaired by symptoms which were due to the collateral damage the surgeon had produced. Interestingly this fear is still immanent in today's public opinion about disc surgery.

The reduction of collateral damage was the driving force for the two pioneers of lumbar microsurgery. In the same year 1977 Yasargil and Caspar described independently a microsurgical interlaminar approach , Figures 6(a) and 6(b). One year later, it was “Tex” Williams who was the first surgeon to perform this approach in the US. The pioneering work of JA McCulloch made this approach popular in the 90s of the last century and it has become a “gold standard” at least in the neurosurgical community worldwide. Other approaches such as the lateral extraforaminal access have been described in this book as well.


减少附带损伤是两位腰椎显微外科先驱者的动力。同年1977年Yasargil和Caspar独立地描述了显微外科椎间板入路,图6(a)和6(b)。一年后,"Tex " Williams成为美国首次采用上述入路的外科医生。JA McCulloch的开创性工作使这种入路在上世纪90年代流行起来,至少在全球神经外科界,它已成为 "黄金标准"。他写的这本书还介绍了其他入路,如外侧椎间孔外入路。





Figure 6 :  (a) G Yasargil, (b) W Caspar: first description of microsurgical interlaminar approach.

图6 (a) G Yasargil, (b) W Caspar: 首次描述显微外科椎板间入路。

“Microendoscopic discectomy” was described in the beginning of this century as a modification of the microsurgical technique where the surgical microscope is replaced by “open” endoscopy. This technique however did not add any further technical or clinical advantages. However both minimally invasive techniques are practiced with good and reproducible clinical outcomes.


 Lessons Learnt from Microsurgical Techniques


In summary lumbar microsurgery has significantly improved clinical short-term outcomes of lumbar discectomy mainly by reducing iatrogenic collateral damage. Thus, hospitalization times have become shorter, postop pain levels are lower, and intraoperative blood loss as well as the risk of infection is less.

Even though the advantages are obvious, several lessons had to be learnt by the protagonists of such techniques.

Since there is obviously no effect on the long-term outcome of lumbar discectomy, the acceptance especially by the older generation of spine surgeons has been low despite the obvious advantages.

It has been known for many years that long-term outcome of lumbar discectomy has different predictors than the short-term outcome. This is due to the fact that there is a progressive degeneration of the spine which can cause clinical symptoms at other levels which are not related to a previous disc surgery.

However we have learnt that one of the strongest predictors of a good long-term outcome is a good short-term outcome. And we have also learnt that a good short-term outcome is predicted by 2 factors: (1) the efficacy of nerve root compression and (2) the extent of iatrogenic collateral damage to muscles, ligaments, facet joints, nerve, and epidural space.






Part 2: The “Parallel World” of “Percutaneous” and Endoscopic Techniques


It was in 1964 when Lyman Smith published a paper about enzymatic dissolution of the nucleus pulposus, a procedure which he called chemonucleolysis. It was known at that time that an enzyme called Chymopapain, which was derived from the papaya plant, was able to hydrolyze proteoglycans. During experimental work in the 50s of the last century about the effects of papain, there was an interesting incidental finding. Intravenous injection of papain in rabbits resulted in a reversible collapse of rabbit ears, a finding which suggested an effect of this enzyme on cartilage. Similar effects were then reported on cartilage of joints, trachea, larynx, and bronchi. Since further studies on rabbits had shown that this enzyme dissolves the nucleus pulposus, it was Lyman Smith’s idea that an application in contained disc herniations could lead to an “intradiscal decompression”, thus relieving the symptoms from nerve compression due to a bulging lumbar disc.

In the 1980s this procedure became popular as the least invasive technique to treat herniated lumbar discs.

Mid- to long-term outcomes were good, complications were rare, and chemonucleolysis seemed to become a viable alternative to surgical discectomy.

Then something happened which was more a psychological phenomenon than rational based medical evolution. In the 70s, Hijikata, a Japanese surgeon, was fascinated by the posterolateral access to the disc space which was, at that time, in the pre-CT and pre-MRI era, very popular to perform diagnostic discographies (Figure 7). He developed tubes through which he could introduce this approach down to the posterolateral annulus under fluoroscopic control. With special trephines he could perforate the annulus and, using pituitary rongeurs, he could perform what he called “percutaneous nucleotomy”. He published this procedure in a regional scientific journal in Japanese language. This was one of the reasons why this procedure did not gain widespread attention among the surgical community but it was the birth of “percutaneous” and, later, endoscopic discectomy.

1964年,Lyman Smith发表了一篇关于酶溶解髓核的论文,他把这个过程称为化学核溶解。当时人们知道一种名为木瓜凝乳蛋白酶的酶(Chymopapain),这种酶是从木瓜植物中提取的,能够水解蛋白聚糖。在上世纪50年代关于木瓜蛋白酶作用的实验中,有一个有趣的意外发现。在兔子身上静脉注射木瓜蛋白酶会引起兔子耳朵的可逆性塌陷,这一发现表明这种酶对软骨是有影响。对关节、气管、喉和支气管的软骨也有类似的影响。由于对兔子的进一步研究表明这种酶可以溶解髓核,Lyman Smith的想法是,在椎间盘突出的地方应用这种酶可实现“椎间盘内减压”,从而缓解由于腰椎间盘突出引起的神经压迫症状。



随后发生的事情,更多的是一种外科医师对手术技能的执着,而不是基于理性的医学演变。在70年代,日本外科医生Hijikata对通过后外侧入路进入椎间盘间隙非常着迷,当时,在CT 和MRI之前的年代,这是非常流行的诊断椎间盘造影(图7)。他研发了一些管子,在透视下,他可以通过这种入路进入后外侧环。使用特殊的环钻在椎环上打孔,并用垂体咬骨钳,他可进行他所谓的“经皮髓核切除术”。他在一家地区性科学杂志上用日语发表了这一手术过程。这也是这种手术没有在外科界获得广泛关注的原因之一,但它是“经皮”以及后来的内窥镜椎间盘切除术诞生的开始。


Figure 7: Hijikata: first percutaneous nucleotomy, 1975.

图7 Hijikata:1975年第一次进行经皮髓核切除术。

It was the great merit of Parviz Kambin a Philadelphian spine surgeon to further develop this procedure in the 1980s  (Figure 8).

Parviz Kambin是费城的一位脊柱外科医生,他在20世纪80年代进一步发展了这一手术操作,这是他的一大功绩(图8)。


Figure 8: P Kambin: percutaneous discectomy, 1986.

图8 P Kambin:1986年进行经皮椎间盘切除术。

It is the “Kambin triangle” (the safe corridor to the lumbar disc between the exiting nerve root and the superior facet) which reminds us of his pioneering work (Figure 9).



Figure 9: Kambin’s triangle for a safe posterolateral approach.


Schreiber, Suezawa, and Leu were the first to have the idea to perform this percutaneous nucleotomy under visual control using and endoscope (discoscopy) .

The author of this review adopted this technique, refined the instrument set  (Figure 10), and published the results of a randomized controlled trial comparing microdiscectomy with endoscopic posterolateral discectomy.




Figure 10: Early Instrument set for percutaneous endoscopic discectomy.


A more lateral access route was described by Hal Mathews and Tony Yeung in the second half of the 1990s.

This lateral extraforaminal approach enabled the removal of far lateral disc herniations as well as more medially located pathologies because the approach corridor was more parallel to the posterior rim of the annulus (Figure 11).

20世纪90年代后半期,Hal Mathews和Tony Yeung描述了一种更横向的通道。



Figure11: Approach corridor and visual field for transforaminal approach.


Lessons Learnt


The indication spectrum for posterolateral and transforaminal endoscopic techniques was limited, which was one of the reasons why endoscopic discectomy remained at a low level of acceptance among spine surgeons in the 1980s and 1990s.

There were other reasons: the variety of instruments was limited, the optical systems were not as good as nowadays, and the technical advantages as compared to microsurgery were small.



Part 3: From a Nondisruptive to a Disruptive Surgical Technology


But what was the missing link or major step? The answer is simple: endoscopy was used in a “dry” environment because the technical advantages of joint arthroscopy were not applied.

Whereas in joint arthroscopy surgical dissection was performed “under water” with continuous irrigation and suction, this principle was not applied in the spine because of the erroneous assumption that irrigation might not be of help or necessary in non-preformed anatomic spaces. The advantages of continuous irrigation (hemostasis, flushing of small bleeding, identification of the bleeding source, better identification of microanatomy, and separation of tissue layers by simple irrigation) were not realized.

Moreover, the technique focused on lateral extraforaminal approaches, and the most traditional interlaminar approach was believed not to be feasible with such a technique.

This is why “the first wave” of lumbar endoscopic techniques remained a nondisruptive technology.

Things changed in the late 90s. It was the merit of Anthony Yeung who started to consequently apply arthroscopic technology for transforaminal as well as interlaminar approaches (Figure 12).





在90年代末,事情开始发生转变。这是Anthony Yeung的功劳,他逐渐将关节镜技术应用于经椎间孔以及经椎间板入路(图12)。


Figure 12: A Yeung: first application of transforaminal approach under continuous irrigation.

图12:A Yeung:持续灌洗下经椎间孔入路的首次应用

There were three major steps, which transferred spinal endoscopy into a disruptive technology:

(1) “under-water-dissection”: continuous irrigation reduced intra- and postop bleeding and infection rates and significantly improved visibility of anatomic structures;

(2) the range of approaches increased from pure transforaminal or posterolateral to interlaminar because

(3) rongeurs, high-speed drills, and other instruments could be used.

Success rates increased and recurrence rates decreased. Rapidly this technology was adopted mainly in Asian countries.

At the beginning of the 2000s it was Sebastian Rütten, a German spine surgeon, who adopted this technology and applied it for interlaminar endoscopic approaches. This significantly enlarged the indication spectrum of this technology (Figure 13).




(3) 可以使用骨钳、高速磨钻和其他器械。


在21世纪初,德国脊柱外科医生Sebastian Rütten采用了这项技术,并将其应用于经椎板间内窥镜手术。这极大地扩大了这项技术的适应症范围(图13)。


Figure 13: S Rütten: first interlaminar approach and application of arthroscopic technique.

图13  S Rütten:首次经椎板间入路和应用关节镜技术

The current indication spectrum for thoracic and lumbar applications is wide and covers all types of degenerative (and other) pathologies which have been a domain of microsurgical techniques in the past (Table 1)



Table 1

Indications for full-endoscopic posterior/lateral thoracic and lumbar spine surgery.

(i) Decompression of central and   foraminal spinal stenosis

(ii) Decompression of lateral recess   stenosis 

(iii) Removal of all types of disc   herniations incl. difficult cases and recurrent disc herniations 

       (a) Medial disc herniations 

  (b) Down migrated disc herniations

  (c) Bilateral disc herniations

  (d) Recurrent disc herniations 

  (e) Calcified disc herniations 

(iv) Removal of synovial cysts

(v) Removal of epidural hematoma

(vi) Removal of thoracic disc herniations   and decompression of thoracic stenosis 

(vii) Palliative decompression metastases  



(i) 中央和椎间孔椎管狭窄减压

(ii) 侧隐窝狭窄减压

(iii) 切除所有类型的椎间盘突出,包括复杂病例和复发性椎间盘突出症

  (a) 内侧椎间盘突出症

  (b) 下移的椎间盘突出症

  (c) 双侧椎间盘突出症

  (d) 复发性椎间盘突出症

  (e) 钙化椎间盘突出症

(iv) 切除滑膜囊肿

(v) 清除硬膜外血肿

(vi) 胸椎间盘突出症摘除和胸椎管狭窄症减压

(vii) 转移瘤的姑息性减压


  总 结   

The first attempts of endoscopic lumbar spine surgery date back to the early 1980s. However, only in the last decade this technology has become a disruptive technology with the potential to replace microsurgical techniques especially for degenerative lumbar spine disorders.

The strong input and high acceptance among Asian spine surgeons have triggered a very dynamic clinical and scientific workflow on this topic. A PubMed search for scientific publications on endoscopic lumbar spine surgery shows that more than 80% of the publications have their origin in Asian countries. It has been shown that even though there is a certain learning curve for endoscopic techniques, once the surgeon is familiar with it, he can achieve comparable and sometimes better clinical results as conventional microsurgical operations.

The complication rates of experienced and well-trained surgeons are low.

The iatrogenic collateral damage of the different approaches to the lumbar spine is diminished and most of the procedures can be performed in an outpatient setting.





The Future

   未 来   

Today we are in a stage which I would call “microendoscopic blending” where the dynamics of technical improvement of endoscopic techniques suggests that the overlap of indications for this technology vs. microsurgery will step by step convert into a scenario where endoscopic techniques replace microsurgical techniques. The great challenge is the learning curve and the training of young surgeons. The acceptance of this technology is high among young surgeons but it is the task and duty of the protagonists of the older generation, the hospitals, and the scientific societies to develop learning- and training-concepts to shorten learning curves and to improve technical quality and clinical outcomes.